Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer.
Identifieur interne : 000127 ( Main/Exploration ); précédent : 000126; suivant : 000128Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer.
Auteurs : Savitha Sridharan [États-Unis] ; Alakananda Basu [États-Unis]Source :
- International journal of molecular sciences [ 1422-0067 ] ; 2020.
Abstract
The mechanistic target of rapamycin (mTOR) is a master regulator of protein translation, metabolism, cell growth and proliferation. It forms two complexes, mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 is frequently deregulated in many cancers, including breast cancer, and is an important target for cancer therapy. The immunosuppressant drug rapamycin and its analogs that inhibit mTOR are currently being evaluated for their potential as anti-cancer agents, albeit with limited efficacy. mTORC1 mediates its function via its downstream targets 40S ribosomal S6 kinases (S6K) and eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1). There are two homologs of S6K: S6K1 and S6K2. Most of the earlier studies focused on S6K1 rather than S6K2. Because of their high degree of structural homology, it was generally believed that they behave similarly. Recent studies suggest that while they may share some functions, they may also exhibit distinct or even opposite functions. Both homologs have been implicated in breast cancer, although how they contribute to breast cancer may differ. The purpose of this review article is to compare and contrast the expression, structure, regulation and function of these two S6K homologs in breast cancer.
DOI: 10.3390/ijms21041199
PubMed: 32054043
PubMed Central: PMC7072743
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It forms two complexes, mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 is frequently deregulated in many cancers, including breast cancer, and is an important target for cancer therapy. The immunosuppressant drug rapamycin and its analogs that inhibit mTOR are currently being evaluated for their potential as anti-cancer agents, albeit with limited efficacy. mTORC1 mediates its function via its downstream targets 40S ribosomal S6 kinases (S6K) and eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1). There are two homologs of S6K: S6K1 and S6K2. Most of the earlier studies focused on S6K1 rather than S6K2. Because of their high degree of structural homology, it was generally believed that they behave similarly. Recent studies suggest that while they may share some functions, they may also exhibit distinct or even opposite functions. Both homologs have been implicated in breast cancer, although how they contribute to breast cancer may differ. The purpose of this review article is to compare and contrast the expression, structure, regulation and function of these two S6K homologs in breast cancer.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32054043</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>20</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1422-0067</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>4</Issue><PubDate><Year>2020</Year><Month>Feb</Month><Day>11</Day></PubDate></JournalIssue><Title>International journal of molecular sciences</Title><ISOAbbreviation>Int J Mol Sci</ISOAbbreviation></Journal><ArticleTitle>Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E1199</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/ijms21041199</ELocationID><Abstract><AbstractText>The mechanistic target of rapamycin (mTOR) is a master regulator of protein translation, metabolism, cell growth and proliferation. It forms two complexes, mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 is frequently deregulated in many cancers, including breast cancer, and is an important target for cancer therapy. The immunosuppressant drug rapamycin and its analogs that inhibit mTOR are currently being evaluated for their potential as anti-cancer agents, albeit with limited efficacy. mTORC1 mediates its function via its downstream targets 40S ribosomal S6 kinases (S6K) and eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1). There are two homologs of S6K: S6K1 and S6K2. Most of the earlier studies focused on S6K1 rather than S6K2. Because of their high degree of structural homology, it was generally believed that they behave similarly. Recent studies suggest that while they may share some functions, they may also exhibit distinct or even opposite functions. Both homologs have been implicated in breast cancer, although how they contribute to breast cancer may differ. The purpose of this review article is to compare and contrast the expression, structure, regulation and function of these two S6K homologs in breast cancer.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sridharan</LastName><ForeName>Savitha</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Basu</LastName><ForeName>Alakananda</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType 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Apr;7(2):132-42</Citation><ArticleIdList><ArticleId IdType="pubmed">25801958</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 1991 Nov;11(11):5541-50</Citation><ArticleIdList><ArticleId IdType="pubmed">1922062</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1988 Dec 25;263(36):19455-60</Citation><ArticleIdList><ArticleId IdType="pubmed">2848828</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res. 2010;12(2):202</Citation><ArticleIdList><ArticleId IdType="pubmed">20398329</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res. 2013;15(5):R96</Citation><ArticleIdList><ArticleId IdType="pubmed">24131622</ArticleId></ArticleIdList></Reference><Reference><Citation>Signal Transduct Target Ther. 2017;2:</Citation><ArticleIdList><ArticleId IdType="pubmed">28890840</ArticleId></ArticleIdList></Reference><Reference><Citation>Life Sci. 2015 Jun 15;131:1-10</Citation><ArticleIdList><ArticleId IdType="pubmed">25818187</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2002 Jul 12;277(28):24847-50</Citation><ArticleIdList><ArticleId IdType="pubmed">12036952</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Pharm Des. 2017;23(11):1633-1638</Citation><ArticleIdList><ArticleId IdType="pubmed">27848885</ArticleId></ArticleIdList></Reference><Reference><Citation>Endocr Rev. 2013 Feb;34(1):1-32</Citation><ArticleIdList><ArticleId IdType="pubmed">22947396</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res Treat. 2011 Feb;126(1):93-9</Citation><ArticleIdList><ArticleId IdType="pubmed">21184268</ArticleId></ArticleIdList></Reference><Reference><Citation>Endocr Relat Cancer. 2015 Jun;22(3):331-43</Citation><ArticleIdList><ArticleId IdType="pubmed">25972244</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Biophys Res Commun. 2008 May 2;369(2):382-7</Citation><ArticleIdList><ArticleId IdType="pubmed">18280803</ArticleId></ArticleIdList></Reference><Reference><Citation>Future Oncol. 2019 Jan;15(1):95-102</Citation><ArticleIdList><ArticleId IdType="pubmed">30730779</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2010 Jun 1;70(11):4260-4</Citation><ArticleIdList><ArticleId IdType="pubmed">20424120</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Biochem Cell Biol. 2011 Jan;43(1):47-59</Citation><ArticleIdList><ArticleId IdType="pubmed">20932932</ArticleId></ArticleIdList></Reference><Reference><Citation>Gene. 2014 Dec 1;552(2):255-64</Citation><ArticleIdList><ArticleId IdType="pubmed">25261849</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2010 Feb 5;285(6):3676-84</Citation><ArticleIdList><ArticleId IdType="pubmed">19940156</ArticleId></ArticleIdList></Reference><Reference><Citation>Exp Oncol. 2004 Dec;26(4):294-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15627062</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem J. 2010 Oct 15;431(2):245-55</Citation><ArticleIdList><ArticleId IdType="pubmed">20704563</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1992 Aug 14;257(5072):973-7</Citation><ArticleIdList><ArticleId IdType="pubmed">1380182</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Transl Res. 2014 Jul 18;6(4):361-76</Citation><ArticleIdList><ArticleId IdType="pubmed">25075253</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer (Auckl). 2008 May 23;2:11-16</Citation><ArticleIdList><ArticleId IdType="pubmed">19430575</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 2010 Feb;30(4):908-21</Citation><ArticleIdList><ArticleId IdType="pubmed">19995915</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2011 Jun 10;332(6035):1322-6</Citation><ArticleIdList><ArticleId IdType="pubmed">21659605</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1988 Aug 15;263(23):11473-7</Citation><ArticleIdList><ArticleId IdType="pubmed">3403539</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2006 Oct 20;314(5798):467-71</Citation><ArticleIdList><ArticleId IdType="pubmed">17053147</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1998 Jun 26;273(26):16621-9</Citation><ArticleIdList><ArticleId IdType="pubmed">9632736</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1998 Nov 13;273(46):30061-4</Citation><ArticleIdList><ArticleId IdType="pubmed">9804755</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2009 Mar 6;284(10):6361-9</Citation><ArticleIdList><ArticleId IdType="pubmed">19112174</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer. 2018 Jul;25(4):392-401</Citation><ArticleIdList><ArticleId IdType="pubmed">29086897</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1992 Feb 15;267(5):3325-35</Citation><ArticleIdList><ArticleId IdType="pubmed">1737788</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Breast Cancer. 2003 Jun;4(2):126-37</Citation><ArticleIdList><ArticleId IdType="pubmed">12864941</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2006 Oct 15;66(20):10162-70</Citation><ArticleIdList><ArticleId IdType="pubmed">17047081</ArticleId></ArticleIdList></Reference><Reference><Citation>Exp Oncol. 2004 Dec;26(4):287-93</Citation><ArticleIdList><ArticleId IdType="pubmed">15627061</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2011 Apr 1;71(7):2590-9</Citation><ArticleIdList><ArticleId IdType="pubmed">21427355</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2008 Sep;118(9):3065-74</Citation><ArticleIdList><ArticleId IdType="pubmed">18725988</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 2009 Nov;29(21):5657-70</Citation><ArticleIdList><ArticleId IdType="pubmed">19720745</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Biophys Res Commun. 2004 Jan 9;313(2):437-41</Citation><ArticleIdList><ArticleId IdType="pubmed">14684181</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Signal. 2018 Mar 27;11(523):</Citation><ArticleIdList><ArticleId IdType="pubmed">29588411</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 1999 Sep 9;18(36):5115-9</Citation><ArticleIdList><ArticleId IdType="pubmed">10490848</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Metastasis Rev. 2016 Dec;35(4):515-524</Citation><ArticleIdList><ArticleId IdType="pubmed">27896521</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2005 Aug 15;65(16):7052-8</Citation><ArticleIdList><ArticleId IdType="pubmed">16103051</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Cancer. 2004 Apr 19;90(8):1543-50</Citation><ArticleIdList><ArticleId IdType="pubmed">15083183</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 2003 Feb;23(3):852-63</Citation><ArticleIdList><ArticleId IdType="pubmed">12529391</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 2011 Dec;31(24):4917-27</Citation><ArticleIdList><ArticleId IdType="pubmed">21986499</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1992 Jul 2;358(6381):70-3</Citation><ArticleIdList><ArticleId IdType="pubmed">1614535</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 2007 Mar 22;26(13):1932-40</Citation><ArticleIdList><ArticleId IdType="pubmed">17001314</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 1999 Sep 9;18(36):5108-14</Citation><ArticleIdList><ArticleId IdType="pubmed">10490847</ArticleId></ArticleIdList></Reference><Reference><Citation>Appl Biochem Biotechnol. 2018 Dec;186(4):1074-1089</Citation><ArticleIdList><ArticleId IdType="pubmed">29862445</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 2004 Apr;24(8):3112-24</Citation><ArticleIdList><ArticleId IdType="pubmed">15060135</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mammary Gland Biol Neoplasia. 2000 Jul;5(3):271-81</Citation><ArticleIdList><ArticleId IdType="pubmed">14973389</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Oncol. 2013 Jul 24;3:191</Citation><ArticleIdList><ArticleId IdType="pubmed">23898460</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2008 Dec 19;283(51):35375-82</Citation><ArticleIdList><ArticleId IdType="pubmed">18952604</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2004 Dec 1;64(23):8541-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15574760</ArticleId></ArticleIdList></Reference><Reference><Citation>Tumour Biol. 2017 Jun;39(6):1010428317710825</Citation><ArticleIdList><ArticleId IdType="pubmed">28639903</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14056-61</Citation><ArticleIdList><ArticleId IdType="pubmed">17709744</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Biol Toxicol. 2013 Aug;29(4):273-82</Citation><ArticleIdList><ArticleId IdType="pubmed">23942996</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2011 Jun 10;332(6035):1317-22</Citation><ArticleIdList><ArticleId IdType="pubmed">21659604</ArticleId></ArticleIdList></Reference><Reference><Citation>J Natl Cancer Inst. 2000 Aug 2;92(15):1252-9</Citation><ArticleIdList><ArticleId IdType="pubmed">10922410</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2017 Mar 16;12(3):e0173854</Citation><ArticleIdList><ArticleId IdType="pubmed">28301598</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2006 Oct 20;281(42):31188-201</Citation><ArticleIdList><ArticleId IdType="pubmed">16895915</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 2012 Dec 6;31(49):5073-80</Citation><ArticleIdList><ArticleId IdType="pubmed">22286763</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Biol. 2004 Jul 19;166(2):213-23</Citation><ArticleIdList><ArticleId IdType="pubmed">15249583</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Oncol. 2014 Dec;25(12):2357-62</Citation><ArticleIdList><ArticleId IdType="pubmed">25231953</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 2011 Nov 3;30(44):4509-22</Citation><ArticleIdList><ArticleId IdType="pubmed">21602892</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2002 Aug 30;277(35):31423-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12087098</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Biol. 2002 Apr 16;12(8):632-9</Citation><ArticleIdList><ArticleId IdType="pubmed">11967149</ArticleId></ArticleIdList></Reference><Reference><Citation>Pharmacol Ther. 2017 Jul;175:91-106</Citation><ArticleIdList><ArticleId IdType="pubmed">28216025</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 2010 Sep 1;29(17):2994-3006</Citation><ArticleIdList><ArticleId IdType="pubmed">20657550</ArticleId></ArticleIdList></Reference><Reference><Citation>J Recept Signal Transduct Res. 2018 Apr;38(2):95-100</Citation><ArticleIdList><ArticleId IdType="pubmed">29619877</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8351-6</Citation><ArticleIdList><ArticleId IdType="pubmed">9653190</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2010 May 28;285(22):17065-76</Citation><ArticleIdList><ArticleId IdType="pubmed">20308064</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 2001 Aug 15;20(16):4370-9</Citation><ArticleIdList><ArticleId IdType="pubmed">11500364</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Biophys Res Commun. 1998 Dec 18;253(2):470-6</Citation><ArticleIdList><ArticleId IdType="pubmed">9878560</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 2000 Dec 15;14(24):3093-101</Citation><ArticleIdList><ArticleId IdType="pubmed">11124802</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 2015 Jan 22;34(4):413-23</Citation><ArticleIdList><ArticleId IdType="pubmed">24469061</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Med Rep. 2015 Oct;12(4):5246-54</Citation><ArticleIdList><ArticleId IdType="pubmed">26151180</ArticleId></ArticleIdList></Reference><Reference><Citation>FEBS J. 2006 May;273(9):2023-36</Citation><ArticleIdList><ArticleId IdType="pubmed">16640565</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 2001 Nov 15;20(52):7658-67</Citation><ArticleIdList><ArticleId IdType="pubmed">11753643</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell Biol. 2012 May;32(10):1818-29</Citation><ArticleIdList><ArticleId IdType="pubmed">22431522</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1999 Sep 24;285(5436):2126-9</Citation><ArticleIdList><ArticleId IdType="pubmed">10497130</ArticleId></ArticleIdList></Reference><Reference><Citation>Anticancer Res. 2013 Feb;33(2):469-75</Citation><ArticleIdList><ArticleId IdType="pubmed">23393338</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Pharm Des. 2012;18(19):2766-77</Citation><ArticleIdList><ArticleId IdType="pubmed">22475451</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Rev Oncog. 2012;17(1):69-95</Citation><ArticleIdList><ArticleId IdType="pubmed">22471665</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Biophys Res Commun. 2007 Oct 19;362(2):330-3</Citation><ArticleIdList><ArticleId IdType="pubmed">17707343</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2015 Dec 23;10(12):e0145013</Citation><ArticleIdList><ArticleId IdType="pubmed">26698305</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncol Lett. 2015 Aug;10(2):829-834</Citation><ArticleIdList><ArticleId IdType="pubmed">26622578</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 1992 Jan 4;339(8784):1-15</Citation><ArticleIdList><ArticleId IdType="pubmed">1345950</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 2005 Sep 15;19(18):2199-211</Citation><ArticleIdList><ArticleId IdType="pubmed">16166381</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Mutat. 2012 Jul;33(7):1123-32</Citation><ArticleIdList><ArticleId IdType="pubmed">22461340</ArticleId></ArticleIdList></Reference><Reference><Citation>F1000Res. 2018 Aug 23;7:1332</Citation><ArticleIdList><ArticleId IdType="pubmed">30705751</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3441-6</Citation><ArticleIdList><ArticleId IdType="pubmed">20133650</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Biochem Cell Biol. 2009 Apr;41(4):828-33</Citation><ArticleIdList><ArticleId IdType="pubmed">18786649</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Chromosomes Cancer. 2011 Oct;50(10):775-87</Citation><ArticleIdList><ArticleId IdType="pubmed">21748818</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2011 Feb 25;286(8):6510-20</Citation><ArticleIdList><ArticleId IdType="pubmed">21177869</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 1992 Jun 26;69(7):1227-36</Citation><ArticleIdList><ArticleId IdType="pubmed">1377606</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2000 Dec 21-28;408(6815):994-7</Citation><ArticleIdList><ArticleId IdType="pubmed">11140689</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Cancer. 2014 Mar;50(5):867-75</Citation><ArticleIdList><ArticleId IdType="pubmed">24440085</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2006 Feb 1;66(3):1500-8</Citation><ArticleIdList><ArticleId IdType="pubmed">16452206</ArticleId></ArticleIdList></Reference><Reference><Citation>Semin Cell Dev Biol. 2004 Apr;15(2):161-70</Citation><ArticleIdList><ArticleId IdType="pubmed">15209375</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Cell. 2003 Jun;11(6):1457-66</Citation><ArticleIdList><ArticleId IdType="pubmed">12820960</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 1998 Nov 16;17(22):6649-59</Citation><ArticleIdList><ArticleId IdType="pubmed">9822608</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2011 May 15;71(10):3669-75</Citation><ArticleIdList><ArticleId IdType="pubmed">21444676</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Cancer. 2006 Sep;6(9):729-34</Citation><ArticleIdList><ArticleId IdType="pubmed">16915295</ArticleId></ArticleIdList></Reference><Reference><Citation>Exp Oncol. 2005 Jun;27(2):141-4</Citation><ArticleIdList><ArticleId IdType="pubmed">15995633</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Biol. 2004 Sep 21;14(18):1650-6</Citation><ArticleIdList><ArticleId IdType="pubmed">15380067</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Cancer. 1990 Apr;26(4):423-9</Citation><ArticleIdList><ArticleId IdType="pubmed">2141507</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Rep. 2013 Jan 31;3(1):103-15</Citation><ArticleIdList><ArticleId IdType="pubmed">23273915</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Signal. 2013 May;25(5):1054-63</Citation><ArticleIdList><ArticleId IdType="pubmed">23403125</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Transl Oncol. 2009 Oct;11(10):643-50</Citation><ArticleIdList><ArticleId IdType="pubmed">19828406</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2008 Sep 15;68(18):7409-18</Citation><ArticleIdList><ArticleId IdType="pubmed">18794129</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2012 Sep 1;11(17):3159-65</Citation><ArticleIdList><ArticleId IdType="pubmed">22895181</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Med Rep. 2018 Mar;17(3):4619-4626</Citation><ArticleIdList><ArticleId IdType="pubmed">29328379</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1988 Jan;85(2):406-10</Citation><ArticleIdList><ArticleId IdType="pubmed">3257566</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2003 Aug 29;278(35):32493-6</Citation><ArticleIdList><ArticleId IdType="pubmed">12842888</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Clin Oncol. 2010 Mar;7(3):139-47</Citation><ArticleIdList><ArticleId IdType="pubmed">20125090</ArticleId></ArticleIdList></Reference><Reference><Citation>Breast Cancer Res Treat. 2011 Aug;128(3):713-23</Citation><ArticleIdList><ArticleId IdType="pubmed">20953835</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Cancer. 2014 Mar;50(5):876-84</Citation><ArticleIdList><ArticleId IdType="pubmed">24456794</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Dermatol. 2011 Jan;50(1):13-20</Citation><ArticleIdList><ArticleId IdType="pubmed">21182496</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Biophys Res Commun. 2013 Mar 1;432(1):123-8</Citation><ArticleIdList><ArticleId IdType="pubmed">23376066</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9666-70</Citation><ArticleIdList><ArticleId IdType="pubmed">11493700</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Biochem. 2014 Jun;115(6):1048-62</Citation><ArticleIdList><ArticleId IdType="pubmed">23564320</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2001 Mar 16;276(11):7892-8</Citation><ArticleIdList><ArticleId IdType="pubmed">11108720</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncologist. 2011;16(4):404-14</Citation><ArticleIdList><ArticleId IdType="pubmed">21406469</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Cancer Res. 2016 Mar 15;22(6):1421-31</Citation><ArticleIdList><ArticleId IdType="pubmed">26542058</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Endocrinol. 2011 Mar;25(3):516-28</Citation><ArticleIdList><ArticleId IdType="pubmed">21292829</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 2010 Feb 18;29(7):1003-16</Citation><ArticleIdList><ArticleId IdType="pubmed">19935711</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4438-42</Citation><ArticleIdList><ArticleId IdType="pubmed">10200280</ArticleId></ArticleIdList></Reference><Reference><Citation>Recent Pat Anticancer Drug Discov. 2010 Jan;5(1):29-57</Citation><ArticleIdList><ArticleId IdType="pubmed">19751211</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Mol Cell Biol. 2008 Oct;9(10):747-58</Citation><ArticleIdList><ArticleId IdType="pubmed">18813292</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO J. 2004 Apr 21;23(8):1761-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15071500</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Biochem Cell Biol. 2010 Feb;42(2):359-66</Citation><ArticleIdList><ArticleId IdType="pubmed">19961954</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2012 Apr 18;486(7403):346-52</Citation><ArticleIdList><ArticleId IdType="pubmed">22522925</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1999 Aug 27;274(35):24731-6</Citation><ArticleIdList><ArticleId IdType="pubmed">10455142</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2009 May 19;4(5):e5618</Citation><ArticleIdList><ArticleId IdType="pubmed">19479038</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Sridharan, Savitha" sort="Sridharan, Savitha" uniqKey="Sridharan S" first="Savitha" last="Sridharan">Savitha Sridharan</name></region><name sortKey="Basu, Alakananda" sort="Basu, Alakananda" uniqKey="Basu A" first="Alakananda" last="Basu">Alakananda 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